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Generated February 18, 2018

Method of reducing TNF.alpha. levels with amino substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxo-and 1,3-dioxoisoindolines

Patent Number: 5,635,517

Patent Information

Abstract
1-Oxo- and 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl) isoindolines substituted with amino in the benzo ring reduce the levels of TNF.alpha. in a mammal. A typical embodiment is 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-5-aminoisoindoline.
Patent Number: 5,635,517
Issue Date: 1997-06-03

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Citations

Patents that cite this patent

Patent Title
9,290,475 3-(substituted-4-oxoquinazolin-3(4
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9,133,161 Processes for preparing isoindoline-1,3-dione compounds
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9,096,573 6-, 7-, or 8-substituted quinazolinone derivatives and compositions comprising and methods of using the same
9,090,585 2,6-dioxo-3-deutero-piperdin-3-yl-isoindoline compounds
9,085,563 Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors
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9,084,783 Thio compounds
9,056,120 Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
9,056,103 Methods using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
9,050,324 Methods for treating amyloidosis with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione
9,045,520 Synthesis of purine nucleosides
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8,957,045 Nucleoside phosphoramidates
8,946,265 Process for the preparation of lenalidomide
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8,916,146 Treatment of inflammatory diseases using placental stem cells
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8,877,180 Human placental collagen compositions, and methods of making and using the same
8,859,756 Stereoselective synthesis of phosphorus containing actives
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8,821,857 Human placental collagen compositions and methods of making and using the same
8,802,685 Solid forms of 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses
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7,834,033 Methods for treating cancer using 3-[1,3dioxo-4-benzamidoisoindolin-2-yl]-2,6-dioxo-5-hydroxypiperidine
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7,393,863 Methods of using N-{[2-(2,6-dioxo(3-piperidyl)-1,3-dioxoisoindolin-4-yl]methyl}cyclopropyl-carboxamide for the treatment and management of myelodysplastic syndromes
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6,235,756 Methods and compositions for inhibition of angiogenesis by thalidomide
5,874,448 Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNF.alpha. levels

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