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Generated February 18, 2018

Inhibitors of TNF-.alpha. secretion

Patent Number: 5,629,285

Patent Information

Abstract
Compounds and methods are disclosed that are useful in inhibiting the TNF-.alpha. converting enzyme (TACE) responsible for cleavage of TNF-.alpha. precursor to provide biologically active TNF-.alpha.. The compounds employed in the invention are peptidyl derivatives having active groups capable of inhibiting TACE such as, hydroxamates, thiols, phosphoryls and carboxyls.
Patent Number: 5,629,285
Issue Date: 1997-05-13

Primary Category

Biographical Information

Executive Summary

Summary

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Patent Grant Time

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Patent Claims

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Proximity to Basic Research

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Proximity to Basic Research

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Citations

Patents that cite this patent

Patent Title
9,211,410 Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
9,211,409 Methods and systems for reducing inflammation by neuromodulation of T-cell activity
9,174,041 Nerve cuff with pocket for leadless stimulator
9,162,064 Neural stimulation devices and systems for treatment of chronic inflammation
8,996,116 Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
8,914,114 Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
8,886,339 Nerve cuff with pocket for leadless stimulator
8,855,767 Neural stimulation devices and systems for treatment of chronic inflammation
8,788,034 Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
8,729,129 Neural tourniquet
8,722,631 Soluble tumor necrosis factor receptor treatment of medical disorders
8,612,002 Neural stimulation devices and systems for treatment of chronic inflammation
8,412,338 Devices and methods for optimizing electrode placement for anti-inflamatory stimulation
8,410,060 Soluble tumor necrosis factor receptor treatment of medical disorders
8,391,970 Devices and methods for inhibiting granulocyte activation by neural stimulation
8,119,605 Soluble tumor necrosis factor receptor treatment of medical disorders
8,093,216 Method of treating cancer by inhibition of p95HER-2 production
7,915,225 Soluble tumor necrosis factor receptor treatment of medical disorders
7,695,948 Antibodies that bind TNF-α converting enzyme
7,358,352 Nucleic acids encoding human TNF-α convertase
7,199,224 Antibodies that bind TNF-α converting enzyme
7,135,555 Mammalian TNF-α convertases
6,881,407 Method for treating hepatitis
6,797,820 Succinate compounds, compositions and methods of use and preparation
6,632,667 Modulation of L-selectin shedding via inhibition of tumor necrosis factor-| converting enzyme (TACE)
6,555,354 TNF-| converting enzyme
6,406,901 TNF-a converting enzyme
6,406,877 TNF-| converting enzyme
6,384,076 Inhibition or erythrocyte sickling by N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester
6,307,101 Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
6,180,403 Antisense inhibition of tumor necrosis factor alpha converting enzyme (TACE) expression
5,929,278 Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
5,853,977 Mammalian TNF-.alpha. convertases
5,834,435 Inhibition of TNF-.alpha. pleiotropic and cytotoxic effects

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